Endometrium thickness below 7 mm is widely considered not preferable for embryo transfer and is associated with decreased pregnancy rates .Therefore, effective therapeutic approaches for improving endometrial thickness in those women are urgently needed. Granulocyte colony-stimulating factor (G-CSF) is one of the cytokine family members including colony-stimulating factors. It has been reported to have effects on embryo implantation and . Studies have demonstrated a benefit from G-CSF perfusion treatment with repeated implantation failure, suggesting that G-CSF treatment has positive effects on the endometrium .

Intrauterine infusion of platelet-rich plasma (PRP) is a new approach that has been suggested for the treatment of thin endometrium . PRP is blood plasma prepared from fresh whole blood that has been enriched with platelets. It is collected from peripheral veins and contains several growth factors such as vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), platelet derived growth factor (PDGF), transforming growth factor (TGF) and other cytokines that stimulate proliferation and growth. Recently, PRP has been used in several medical conditions in ophthalmology, orthopaedics, surgery and dermatology and now in endometrial growth .